1.M.R (“One More Rep”) by BPI Sports is a heavily-concentrated, mind-blowing dose of energy, vascularity, and strength. Unlike most products that require several scoops to get your motor running for the gym, 1.M.R requires just one scoop pre-workout before you are amped to train. 1.M.R has a unique blend of scientifically-proven ingredients that will cause noticeable changes in energy, strength, and improved vascularity— after one dose. You no longer have to mix different brands of pills and scoopers of your favorite pre-workout supplements, because 1.M.R has everything you need in one scoop!

1.M.R will get you ultra-focused and super-energized with its unique blend of a powerful, pre-workout energizing formula. Let’s take a look at the science behind 1.M.R formulation:

L-arginine alpha-ketogluterate (AAKG): 1.M.R contains L-arginine alpha-ketoglutarate, which is a precursor of nitric oxide. AAKG has been used in the medical field for years to help patients recover from traumatic injury. When taken after surgery, AAKG has been shown to stimulate two anabolic hormones, growth hormone and insulin.¹

The anti-catabolic effects of AAKG were demonstrated when multiple trauma patients who were highly catabolic and hyper-metabolic (losing muscle) were given AAKG. The subjects receiving AAKG showed a significant increase in protein synthesis and an increase in blood levels of insulin, growth hormone, and free amino acids (glutamine, proline and arginine), compared to subjects not receiving AAKG supplements. AAKG supplements result in elevated concentrations of anabolic (growth) hormones and amino acid metabolites, including insulin-like growth factor 1 (IGF-1), glutamine and glutamate, when taken over several weeks.²

In another study of healthy men, AAKG resulted in a 20-30 percent elevation in insulin, which was not observed with supplementation of either arginine or alpha-ketoglutarate alone. Spiking insulin pre-exercise is going to get nutrients into muscle; additionally, insulin is a vasodilator. Taking 1.M.R pre-exercise will spike insulin and anabolic hormones so as you begin exercise, you are in an anabolic state.

Creatine Monohydrate: Creatine has become the mostly widely-researched ergogenic aid to date; the research is overwhelmingly clear that creatine not only increases muscle strength, but creatine does what no other supplement can do— lower myostatin.

In a recent study in the Journal of Molecular and Cellular Endocrinology, researchers examined how creatine impacted myostatin levels in resistance-trained men. In a double-blind design, 27 healthy male subjects were assigned to resistance training and creatine supplementation groups. Amazingly, the study found that creatine supplementation, when added to a resistance-training program, amplifies the training-induced decrease in serum levels of myostatin, increasing the effects of exercise on muscle strength and mass.³ Other studies reported that ingestion of creatine enhances muscle IGF-1 responses, in conjunction with increasing satellite cell activation.⁴

Caffeine/Guarana/Yerba Maté: Caffeine is a wonder drug in terms of metabolism and exercise performance. As you probably read in the Supplement Performance section, a high dose of caffeine is needed to see true performance-enhancing effects in the gym. Back in 1990, researchers found that the dose of caffeine dependently increased resting energy expenditure. The researchers found that the degree of energy expenditure was directly related to the blood caffeine levels. You may notice those abs starting to appear more clearly, as 1.M.R is going to enhance your metabolism and burn more fat. There is evidence that during high-intensity exercise in highly-fit men, caffeine ingestion increases oxygen uptake and enhances fatty acid mobilization from adipose tissue³, and decreases the perception of pain during exercise.⁵ Caffeine has been found to increase testosterone responses in men during exercise.⁶

Guarana comes from the seeds of a South American shrub. The seeds of guarana are known to be rich in caffeine, and have been widely used as a tonic in many South American countries. Guarana has a powerful effect on increasing metabolic rate, suppressing your appetite and enhancing both physical and mental performance. Most of the research suggests that guarana has effects similar to caffeine in that it can reduce fatigue and improve arousal. For example, in a double-blind, placebo-controlled study of 129 healthy young adults, one-time use of guarana plus vitamins and minerals improved mental function and reduced mental fatigue, among those undergoing a battery of cognitive tests.⁸ In another double-blind, placebo-controlled study, use of guarana alone or guarana plus ginseng appeared to improve mental function.⁹

Yerba Maté is rich in antioxidants, chlorophyll and trace minerals. It aids in digestion and boosts mental and physical performance, through mild stimulation of the adrenal glands. Yerba maté is used as a tonic and as a stimulant to reduce fatigue, suppress appetite, and aid gastric function in herbal medicine systems throughout South America. Researchers in Switzerland performed a study on human subjects that indicated yerba maté could be beneficial as a weight-loss aid. They noticed a thermogenic effect in healthy individuals, indicating a rise in the proportion of fat burned as energy.^11,12 Yerba maté extracts have been shown to relax smooth muscle, to increase bile flow, and inhibit vasoconstriction.¹⁰

In sum, the combination of ingredients in 1.M.R is going to rev up your metabolism, reduce fatigue, and get you psyched-up to train!!

Beta-alanine: Beta-alanine increases carnosine, which is a powerful precursor in generating nitric oxide synthase (a group of enzymes necessary for making the powerful vasodilator nitric oxide). Beta-alanine buffers hydrogen ions, which prevent pH levels in muscle from dropping to low levels (more acidic) so as a result, you can train harder and push through the burn for higher reps.⁷ In a more acidic environment (i.e., high lactic acid levels), ATP is less effective and the release of calcium, a key component to muscle contraction, is hindered substantially— so taking beta-alanine is going to significantly enhance your workout performance in the gym. 

Taurine/N-Acetyl Tyrosine: Taurine is conditionally essential amino acid, similar to glutamine. It has numerous effects, some of which could help bodybuilders. For example, it has an insulin-like effect with regard to glucose and amino acid metabolism. Taurine may also be involved in the regulation of the volume in some cells. N-Acetyl Tyrosine supports brain function by improving the synthesis of catecholamines, norepinephrine and dopamine (neurotransmitters). 

Grapeseed Extract, Vitamin C, and Red Wine Extract: 1.M.R also contains an antioxidant blend of vitamin C, grapeseed, and red wine extract. The vasodilation activity of the wines correlates significantly with their antioxidant activity. In addition, the antioxidant activity is associated with other substances present in red wine that have antioxidant effects such as gallic acid, total resveratrol, and total catechins (i.e., tannin). The anthocyanins found in wines are associated with vasodilation activity, which is why 1.M.R included it in their formula.

1.M.R is what separates you from everyone else. It’s what makes every muscle stronger, every vein wider, and every rep shorter. Pack on 100 miles per hour of energy and maybe, just maybe, you have what it takes. BPI Sports’ 1.M.R is a nonstop energy-driven formula. It will get you to the gym faster, make your workouts shorter, and ultimately make you the architect of your own reflection.

For more information, please go to https://bpisports.net. 

References:

1. Jeevanandam M, Petersen SR. Substrate fuel kinetics in enterally fed trauma patients supplemented with Arginine alpha ketoglutarate. Clin Nutr, 1999 Aug;18(4):209-17.

2. Herranz Jordán B, Moreno Romero F, Cardesa García JJ, Santos Hurtado I,Aparicio Palomino A, Requena Guerrero F. [Controlled clinical assay in Clonidine, arginine aspartate, alpha-ketoglutarate of Ornithine and Ciproheptadine as growth stimulants in children with short stature]. An Esp Pediatr, 1993 Jun;38(6):509-15.

3. Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K. Effects of oral creatine and resistance training on serum myostatin and GASP-1. Mol Cell Endocrinol, 2009 Dec 22.

4. Deldicque L, Louis M, Theisen D, Nielens H, Dehoux M, Thissen JP, Rennie MJ, Francaux M. Increased IGF mRNA in human skeletal muscle after creatine supplementation. Med Sci Sports Exerc, 2005 May;37(5):731.

5. Bell, DG., AND T.M. McLellan. Exercise endurance 1, 3, and 6 h after ingestion in caffeine users and nonusers. J Appl Physiol, 93:1227-1234. 2002.

6. Spriet, LL., D.A. Maclean, D.J. Dyke, E. Hultman, G. Cederblad, AND T.E. Graham. Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol Endocrinol Metab, 262:E891-E898. 1992.

7. Giannini Artioli G, Gualano B, Smith A, Stout J, Herbert Lancha A Junior. The Role of beta-alanine Supplementation on Muscle Carnosine and Exercise Performance. Med Sci Sports Exerc, 2009.

8. Kennedy DO, Haskell CF, Wesnes KA, et al. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. PharmacolBiochem Behav, 2004;79:401-11.

9. Kennedy DO, Haskell CF, Robertson B, et al. Improved cognitive performance and mental fatigue following a multivitamin and mineral supplement with added guarana (Paullinia cupana). Appetite, 2007 Oct 30.

10. Paganini Stein, F. L., et al. “Vascular responses to extractable fractions of Ilex paraguariensis in rats fed standard and high-cholesterol diets.” Biol Res Nurs, 2005 Oct; 7(2): 146-56.

11. Anderson, T., et al. “Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients.” J Hum Nutr Diet, 2001; 14(3): 243-50.
12. Martinet, A., et al. “Thermogenic effects of commercially available plant preparations aimed at treating human obesity.” Phytomedicine, 1999; 6(4): 231-38.