Written by DR. GEORGE TOULIATOS
20 November 2019

 

 

 

 

 

 

 

 

Dr. Testosterone
By George Touliatos, MD

 

  1. TRENBOLONETtenbolone is a 19-nortestosterone derivative with a chemical structure resembling nandrolone. It is of high androgenicity and anabolic activity (about five times higher that testosterone), ideal during pre-contest preparation and dieting.

 

Trenbolone has a positive effect on fat burning and catabolism of adipose tissue (beta oxidation). It is a progestin, leading to progestational activity, which raises prolactine in the presence of estrogens.

Trenbolone is available in slow, intermediate and fast-acting injectable esters (enanthate, hexahydrobenzylcarbonate, acetate). Acetate and enanthate forms are not for human use, as they are used in veterinary medicine for cattles.

Only Parabolan (trenbolone hexahydrobenzylcarbonate) was available for human use, manufactured by Negma Laboratories in the ‘80s and was discontinued in 1997.

 

Trenbolone enanthate (slow ester) releases 70% of the substance, while the intermediate releases 80%. Fast ester has a short half-life and highest degree of assimilation, even higher than of testosterone propionate (90%). However, for the past five years, a suspension form (trenbolone base 50mg) has been available in the market, with an acute absorbability (100%) and a half-life of 24h.

 

Trenbolone presents negative impact on serum lipids [decreased high-density lipoprotein (HDL), increased low-density lipoprotein (LDL) and triglycerides] and may increase systemic blood pressure. All these factors are associated with an increased risk of atherosclerosis and coronary heart disease.

As a progestational steroid, trenbolone raises prolactine. Apart from aesthetic issues of gynecomastia, prolactinemia also affects libido and sexual drive.

Dopamine agonists (bromocriptine, cabergoline) should be used along with trenbolone, in order to improve libido, by lowering serum prolactine.

 

Androgenic side effects include acne, body/facial hair growth, male pattern hair loss (MPB-androgenic alopecia) and benign prostate hyperplasia (BPH).

Studies have shown that trenbolone plays critical roles in neurodegeneration and apoptosis in hippocampus-amygdala. Hippocampus is a certain area in mesencephalon, belonging to the limbic system, associated with behavior.

Abuse can develop episodes of insomnia, aggression (physical and verbal), irritability, anxiety, neurosis, mood swings-emotional instability, manic episodes, depression and rarely psychosis-misconceptions, while Alzheimer’s disease is also linked with chronic abuse of trenbolone.

 

The authenticity of the fast ester is noticed by the appearance of the typical “tren cough’’ soon after the intramuscular injection. High concentration of trenbolone acetate, along with the presence of benzalkonium (alcohol with distinctive smell) can directly irritate lung tissue. These substances cause an asthmatic crisis with bronchospasm and symptoms of paroxysmal coughing, wheezing, rapid breathing or chest pressure. Immediate use of bronchodilators such as inhaled salbutamol is necessary.

Another factor that is responsible for “tren cough’’ is the introduction of a small amount of oil into small blood vessels, or the lymphatic system during intramuscular injection.

Trenbolone is known to cause a reduction of aerobic capacity, and based on the fact that it is a “cortisol crusher,” trenbolone stimulates inflammation. Therefore, inflammatory cytokines-prostaglandins (PGs) in the respiratory system trigger bronchospasm and infections, leading to poor respiratory capacity (VO2max).

 

On the other hand, the “cortisol crush” makes trenbolone highly anabolic. As known, cortisol (glucocorticoid) is considered to be a muscle catabolic hormone. Since cortisol induces hyperglycemia through gluconeogenesis, trenbolone’s use will lead to hypoglycemia.

 

Trenbolone is considered as a pre-contest anabolic steroid, since there is no water retention and edema effect, based on aldosterone’s and cortisol’s inhibition from the kidneys. On the contrary, cortisol’s crush leads to joint discomfort, since cortisol is known to mask pain and soothe joint aches.

 

People with increased muscle mass (BMI>30) also have elevated levels of creatinine, as the striated-skeletal muscles have more creatine, even when it is not exogenously obtained in the form of monohydrate powder.

 

Trenbolone combined with creatine and diuretics can cause renal strain and elevation of indexes.

Increased blood pressure derived from the action of clenbuterol hydrochloride (beta2-agonists) can potentially cause sclerosis of the renal tubules because of extensive vasoconstriction, which leads to an increase of blood pressure.

 

George Touliatos, MD is an author, lecturer, champion competitive bodybuilder and expert in medical prevention regarding PED use in sports. Dr. Touliatos specializes in medical biopathology and is the medical associate of Orthobiotiki.gr and Medihall.gr, Age Management and Preventive Clinics in Athens, Greece. Heis the author of four Greek books on bodybuilding, has extensively developed articles for www.anabolic.org and is the medical associate for the book Anabolics, 11th Edition (2017). Dr. Touliatos has been a columnist for the Greek editions of MuscleMag and Muscular Development magazines, and has participated in several seminars across Greece and Cyprus, making numerous TV and radio appearances, doing interviews in print and online. His personal website is

 

 

https://gtoul.com/

 

 

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