Written by William Llewellyn
29 May 2018

16anabolics101-parabolin

Anabolics 101 - Featuring Parabolin (Trenbolone)

 

 

Description

Parabolan is the most recognized brand name for trenbolone hexahydrobenzylcarbonate, a slow-acting injectable ester of the potent anabolic steroid trenbolone. Trenbolone appears most commonly as trenbolone acetate, which is a much faster-acting form of the drug. The hexahydrobenzylcarbonate ester used here extends the release of trenbolone for more than two weeks, which has always been thought of as more suitable for human use due to the less frequent injection schedule. The base steroid trenbolone is roughly three times more androgenic than testosterone, making it a fairly potent androgen. It also displays about three times greater tissue-building activity in comparison to its androgenic properties, making its official classification as that of an anabolic steroid. The muscle-building effect of trenbolone is often compared to such popular bulking agents as testosterone or Dianabol, but without the same estrogen-related side effects. It is most commonly identified as a lean-mass-building drug, and is extremely popular with athletes for its ability to promote the rapid buildup of strength, muscle size and definition.

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How Supplied

Parabolan is an injectable medication. It is usually prepared as 50 mg/mL or 100 mg/mL of steroid dissolved in oil.

 

Effective Dosages

For physique- or performance-enhancing purposes by men, trenbolone hexahydrobenzylcarbonate is most often administered at a dosage of 152-220 milligrams per week. The drug would be taken in cycles ranging from six to 12 weeks. Although a weekly administration schedule would be more than sufficient, athletes usually injected a single ampule (76 mg) at a time, and the total amount would be spread evenly throughout the week. Although not necessary, this type of schedule helps to reduce injection volume per application. The results with the use of trenbolone hexahydrobenzylcarbonate should be a visibly more muscular physique (larger, leaner) and, if body fat levels are low enough, that hard and ripped look most valued by dieting and competitive bodybuilders. This agent is generally not recommended for women for physique- or performance-enhancing purposes, due to its strong androgenic nature and tendency to produce virilizing side effects.

 

Side Effects

Estrogenic: Trenbolone is not aromatized by the body, and is not measurably estrogenic. It is of note, however, that this steroid displays significant binding affinity for the progesterone receptor (slightly stronger than progesterone itself). The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an anti-estrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by progestational anabolic-androgenic steroids (AAS). Note that progestational side effects are more common when trenbolone is being taken with other aromatizable steroids.

 

Androgenic: Although classified as an anabolic steroid, trenbolone is sufficiently androgenic. Androgenic side effects are still common with this substance, and may include bouts of oily skin, acne and body/facial hair growth. Anabolic-androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of AAS. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth and clitoral enlargement. Additionally, the 5-alpha reductase enzyme does not metabolize trenbolone, so its relative androgenicity is not affected by finasteride or dutasteride.

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Liver Toxicity:Trenbolone is not c-17 alpha alkylated, and is generally not considered a hepatotoxic steroid; liver toxicity is unlikely. This steroid does have a strong level of resistance to hepatic breakdown, however, and severe liver toxicity has been noted in bodybuilders abusing trenbolone. Although unlikely, hepatotoxicity cannot be completely excluded, especially with high doses.

 

Cardiovascular: Anabolic-androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an AAS on serum lipids is dependant on the dose, route of administration (oral versus injectable), type of steroid (aromatizable or non-aromatizable) and level of resistance to hepatic metabolism. Due to its non-aromatizable nature and strong resistance to metabolism, trenbolone has a moderate to strong (negative) impact on lipid values and atherogenic risk. Anabolic-androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

 

Testosterone Suppression: All AAS, when taken in doses sufficient to promote muscle gain, are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within one to four months of drug cessation. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. In experimental studies, trenbolone was determined to be approximately three times stronger at suppressing gonadotropins than testosterone, on a milligram-for-milligram basis.

The above side effects are not inclusive.

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Availability

Pharmaceutical preparations containing trenbolone hexahydrobenzylcarbonate are scarce. Most products sold on the black market are of underground origin.

  

References:

- Mathieu J. Proc Intern Symp; Drug Res 1967, p 134. Chem Inst Can, Montreal, Canada.

- Ojasoo R. Unique steroid congeners for receptor studies. Cancer Research 38;1978:4186-98.

- Bauer Meyer, et al. Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor. Acta Pathol Microbiol Imunol Scand Suppl 108;2000:838-46.

- Ojasoo R. Unique steroid congeners for receptor studies. Cancer Research 38;1978:4186-98.

- Spranger M. Disposition of 17 beta-trenbolone in humans. J Chromatogr 564;1991:485-92.

- Anand JS, et al. Cholestasis induced by Parabolan successfully treated with the molecular adsorbent recirculating system. ASAIO 2006;JanFeb;52(1):117-8.

 

About the Author:

William Llewellyn is the author of the anabolic steroid reference guide, ANABOLICS 10th Edition. He is also a longtime team member at Muscular Development, having been a regular monthly columnist since 2002. William adapted this steroid profile from his work at anabolic.org. He is also credited with helping to develop ROIDTEST™, an at-home steroid testing kit used to identify real and fake steroid products.

 

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